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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CANX
All Species:
40.91
Human Site:
S431
Identified Species:
60
UniProt:
P27824
Number Species:
15
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P27824
NP_001019820.1
592
67568
S431
L
E
L
W
S
M
T
S
D
I
F
F
D
N
F
Chimpanzee
Pan troglodytes
XP_001151304
592
67554
S431
L
E
L
W
S
M
T
S
D
I
F
F
D
N
F
Rhesus Macaque
Macaca mulatta
XP_001101429
592
67582
S431
L
E
L
W
S
M
T
S
D
I
F
F
D
N
F
Dog
Lupus familis
XP_533285
610
69806
S420
L
E
L
W
S
M
T
S
N
I
Y
F
D
N
F
Cat
Felis silvestris
Mouse
Mus musculus
P35564
591
67259
S432
L
E
L
W
S
M
T
S
D
I
F
F
D
N
F
Rat
Rattus norvegicus
P35565
591
67236
S432
L
E
L
W
S
M
T
S
D
I
F
F
D
N
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506871
598
67609
S434
L
E
L
W
S
M
T
S
D
I
F
F
D
N
F
Chicken
Gallus gallus
NP_001025791
599
68090
S432
L
E
L
W
S
M
T
S
D
I
F
F
D
N
F
Frog
Xenopus laevis
NP_001080326
611
69964
S443
L
E
L
W
S
M
T
S
D
I
F
F
D
N
F
Zebra Danio
Brachydanio rerio
NP_998613
600
67856
S439
L
E
L
W
S
M
S
S
D
I
F
F
D
N
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29413
406
46790
L314
L
R
K
E
I
C
T
L
G
F
D
L
W
Q
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34652
619
69189
E423
I
E
M
W
T
M
S
E
N
I
L
F
D
N
I
Sea Urchin
Strong. purpuratus
XP_791226
591
66512
D425
L
E
L
W
S
M
S
D
K
I
L
F
D
N
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9SP22
420
47921
V328
I
G
I
E
L
W
Q
V
K
S
G
T
L
F
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P29402
530
60468
D377
I
E
I
W
T
M
Q
D
G
I
L
F
D
N
I
Baker's Yeast
Sacchar. cerevisiae
P27825
502
56949
L397
N
V
I
S
G
V
I
L
E
F
W
S
G
S
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.6
59.1
N.A.
93
93.5
N.A.
85.7
82.8
78.2
70.8
N.A.
31.7
N.A.
40.5
53.7
Protein Similarity:
100
99.8
99.4
75.2
N.A.
96.6
97.4
N.A.
93.1
90.8
86.2
84.1
N.A.
44.7
N.A.
58.9
69.7
P-Site Identity:
100
100
100
86.6
N.A.
100
100
N.A.
100
100
100
93.3
N.A.
13.3
N.A.
46.6
73.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
13.3
N.A.
80
80
Percent
Protein Identity:
N.A.
29.3
N.A.
40
25.6
N.A.
Protein Similarity:
N.A.
44.4
N.A.
53.5
41.2
N.A.
P-Site Identity:
N.A.
0
N.A.
46.6
0
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
66.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
13
57
0
7
0
82
0
7
% D
% Glu:
0
82
0
13
0
0
0
7
7
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
13
57
82
0
7
69
% F
% Gly:
0
7
0
0
7
0
0
0
13
0
7
0
7
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
19
0
19
0
7
0
7
0
0
82
0
0
0
0
13
% I
% Lys:
0
0
7
0
0
0
0
0
13
0
0
0
0
0
0
% K
% Leu:
75
0
69
0
7
0
0
13
0
0
19
7
7
0
0
% L
% Met:
0
0
7
0
0
82
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
0
0
0
0
13
0
0
0
0
82
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% P
% Gln:
0
0
0
0
0
0
13
0
0
0
0
0
0
7
0
% Q
% Arg:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
7
69
0
19
63
0
7
0
7
0
7
0
% S
% Thr:
0
0
0
0
13
0
63
0
0
0
0
7
0
0
0
% T
% Val:
0
7
0
0
0
7
0
7
0
0
0
0
0
0
7
% V
% Trp:
0
0
0
82
0
7
0
0
0
0
7
0
7
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _